Ring opening/fragmentation of dihydropyrones for the synthesis of homopropargyl alcohols.
نویسندگان
چکیده
Ring-opening/C-C bond cleavage reactions induced by nucleophilic addition of methyl Grignard to 5,6-dihydro-2-pyrone (DHP) triflates 1 furnish homopropargyl alcohols (1 --> 2) stereospecifically with respect to the stereochemistry of 1. Carbonyl extrusion from DHP triflates provides a unified and operationally simple strategy for preparing chiral homopropargyl alcohols.
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ورودعنوان ژورنال:
- Journal of the American Chemical Society
دوره 130 15 شماره
صفحات -
تاریخ انتشار 2008